The sample of amniotic fluid will be retrieval by transabdominal amniocentesis. The bacterial load of genital mycoplasmas/Streptococcus agalactiae with different quantification approach along with intensity of intraamniotic inflammatory response to bacteria by a panel of cytokines, chemokines and alarmins will be determined.
The critical values of microbial burden responsible for exhibition of intensive intraamniotic infection and inflammation will be proposed. These values will be described for three different periods of pregnancy. Clinical observations will be verified with using of amnio-chorion explant model.
The efficacy of threshold cycle value of real time PCR will be validated by absolute quantification approach.

The main target of the project is to employ advanced thin film preparation techniques (pulsed laser deposition, magnetron sputtering) for the fabrication of high-quality heterostructures based on chalcogenide materials. The final goal will be to fabricate and characterize
heterostructures for environmental or medical detection and nonlinear optical devices. The fabrication of thin amorphous chalcogenide films and their detailed characterization will be investigated in the frame of the project. The study of heterostructures will be performed considering the compatibility of silicon, dielectric materials as SiO2, Al2O3 and gold with chalcogenides and the optimization of interfaces between the different layers. The results of the project will contribute to deepen the fundamental knowledge about the thin film fabrication processes and their use in the field of photonics. It is expected that obtained results will clearly demonstrate the ability of fabricated chalcogenide-based heterostructures for use in nonlinear optical devices and optical sensors.

The project focuses on design and synthesis of novel organic selenium derivatives and their subsequent application as Se-precursors suitable for 2D transition-metal dichalcogenides by atomic layer deposition (ALD). The proposed strategy involves four logically ordered work packages that include design, synthesis, purification and fundamental characterization of new volatile selenium derivatives, their utilization as Se-precursors for ALD, optimization of the ALD process towards layers of 2D transition-metal dichalcogenides, their characterization and further assessment of their application potential. The main motivation for the project is missing portfolio
of selenium or tellurium derivatives suitable for ALD technique as well as application of the ALD technique for preparing MoSe2 and related nanomaterials. The project is highly multidisciplinary on the forefront of organic, inorganic and materials chemistry and, therefore, also highly collaborative and will involve close collaboration of two working groups of the applicants, both
with unique know-how in the given area.

The project is focused on the development of energy storage technologies for both conventional and renewable energy sources. Organic redox substances with suitable properties for flow and quasi/solid secondary batteries will be sought. The preparation of these substances will be optimized for production costs and chemical purity. We will be exploring applications for use in chemical production (organic oxidation agents), electroseparation processes and sensors. The broad cooperation of researchers, from the University of Chemistry and Technology Prague, the University of Pardubice and the Center of Organic Chemistry Ltd., will enable the development of new practical solutions based on current knowledge. Output from the project will include patent applications and a number of publications with non-Czech co-authors.

The project focuses on the synthesis optimization of efficient and purely organic photoredox catalysts based on 5,6-di(5-alkoxythiophen-2-yl)pyrazine-2,3-dicarbonitrile.

In this project we propose the design, synthesis, and versatile application of organic push-pull molecules featuring
intramolecular charge-transfer. Four principal classes of compounds were envisaged - (thio)barbituric acids-derived systems,
donor 3,6-disubstituted diketopyrrolopyrroles, Thdione derivatives resembling indane-1,3-dione moiety, and imidazolium- and
pyridinium betaine derivatives. The final property tuning will be accomplished in terms of variation of the appended donors
and acceptors, elongation of the p-linker and auxiliary pendants, and counter ion replacement. Synthesized compounds will be
investigated as NLO-active chromophores upon embedding into the polymeric matrix or inorganic carrier, NLO-active ionic
liquids, photovoltaic devices, pH-induced and photochromic NLO-switches, and fluorophores. Strong (inter)national cooperation
with renowned scientist has already been established in this respect.

1) A comprehensive evaluation of current methods for determination of a safety against derailment.
2) Design and realisation of a new mobile test equipment for testing of safety against derailment and carbody movements.
3) Proposal of a new more accurate method for determination of safety against derailment. The new method will be tested using the new test equipment.

The goal of the project is to investigate the concepts of love and friendship that have received increasing attention in the
contemporary Anglo-American discussions in the domain of philosophical psychology and ancient philosophy. Since the
contemporary debates of the problem have been vastly inspired by the ancient Greek thoughts on the subject, the project aims
at integrating two different directions of research ? the systematic and the historical. Treating these two directions together will
help to minimize the deficiencies of partial research: systematic theory of love and friendship that draws inspiration from
ancient conceptions of philia and eros tends to oversimplify these theories, historical approaches on the other hand have the
tendency to neglect the actual impact of their researched topic and the contemporary conceptual distinctions. We will show that
this dialogue, in which the strength of the project lies, is indispensable for both the systematic elaboration of the topic and its
historical treatment in the ancient texts.

The theme of the project is the political crisis of the central Europe which resulted in several years of military conflict within the empire (1546-47) and ending with the so-called Peace of Augsburg (1555). The aim of the project is to oer a new historical interpretation of the signicance of the Bohemian lands in this conflict, primarily with regard to the economic and military potential which they represented in the
central Europe of the time. So far in European historiography this aspect has not been taken into account suciently because the Bohemian lands did not become an active participant of the military conflict. But at the end of the 1540s it was one of the main economic sources which king attempted to utilise as part of his broader power politics. At the time he managed to establish fundamental economic reforms in the Bohemian lands concerning the assertion of monarchical property rights and changes in the tax and currency system. He thus created economic sources both for the power consolidation of the state and for imperial policy in the last decade of his rule.