Assoc. Prof. Dr. Aleš Imramovský

CONTACT INFORMATION

 
Faculty of Chemical Technology
Institute of Organic Chemistry and Technology, Chart of Organic Technology
Studentská 573,
532 10 Pardubice
Contact possibilities:
Via email:       ales.imramovsky (@) upce.cz
Via Phone:      +420 46 603 7739; +420 46 603 7742
Location:
Faculty of Chemical Technology, Tower F, 3rd Floor, Office No.: F3 035 Labs No.:F3 038 and F3 042
 
 
 

BIOGRAPHY

 
EDUCATION
 
2013 University of Pardubice, Faculty of Chemical Technology, Pardubice (Czech Republic).
Habilitation: New Antimicrobial and Antifungal Compounds with Regard to Their Technological Realization. (September 2013)
 
2003 – 2007 Full-time postgraduate education at The Faculty of Pharmacy, Charles University in Prague (Ph.D. study at The Department of Inorganic and Organic Chemistry, specialization: Bioorganic chemistry).
PhD Thesis: Preparation and evaluation of new potential antimicrobial drugs and prodrugs (defense of PhD thesis May 2007).
 
1998 – 2003 University of Pardubice, Faculty of Chemical Technology (magisterial study).
Diploma Thesis: Research Institute for Pharmacy and Biochemistry, Léčiva Co. Prague, Czech republic.
Diploma Thesis Title: Synthesis of Antidiabetic Pioglitazone – Identification of Concomitant Impurity (defense of thesis June 2003).
 
 
GRANTS AND PROJECTS
Principal Researcher
  • Technology Agency of Czech Republic, Project TA03010819, Title: Development of Technology for non-Halogenated Veterinary Prostaglandins and Their Intermediates. (2013-2016)
  • 2010 Grant FRVŠ 845/2009 Principal Researcher successfully finished with defense
  • 2006 Grant FRVŠ 152/2006 Principal Researcher successfully finished with defense
  • 2005 Grant FRVŠ 297/2005/G6 Principal Researcher, successfully finished with defense
Co-worker:
  • 2011-2013 Project of Grant Agency of Czech Republic. Derivates of Phosgene for nanotechnology.
  • 2012 Grants FRVŠ, Biomedicinal Laboratory, successfully finished with defense
  • 2006 Grant GAUK 285/2006/B-CH/FaF Partially Researcher, grant continue in 2007
 
PUBLICATIONS (September 2014):
Scientific papers:
  • Author or Co-author 34 scientific papers (31 in impact factor journals).In WOS were cited 139 times without self-citations, h-index = 9.
Patents:
  • Co-author of one patents and one pending patent.
Conferences:
  • Author or Co-author more than 66 contributions on national or international professional conferences.
 
PRIZE AND AWARDS
  • Cena Josefa Hlávky, Prague, November 16th 2007. Foundation „Josefa, Marie a Zdeňky Hlávkových“ award prize on the basis nomination of the Dean of the Faculty of Pharmacy, Charles University in Prague. (http://www.hlavkovanadace.cz/).
 
TEACHING ASSIGNMENTS
Graduate programs at the Faculty of Chemical Technology, University of Pardubice
  • Production of pharmaceuticals, Organic Process Intermediates
  • Laboratory of Organic Synthesis and Identification
Undergraduate programs at the Faculty of Chemical Technology, University of Pardubice
  • Pharmaco-chemistry (distance form of education)
  • Organic Chemistry – basic course
  • Laboratory of Organic Chemistry – I
  • Laboratory of Organic Chemistry – II
 
RESEARCH INTERESTS
Research fields
  • Synthesis of original biological active compounds and intermediates
  • Development of new organic technology
  • Improvement of current technological steps
  • New synthetic methods in organic chemistry
  • Preparation of “prodrug form” of current drugs
  • Kinetic study of chosen rearrangements
  • Study of stability of selected prepared compounds
 
SELECTED PUBLICATIONS
  1. Imramovský, A.; Jorda, R.; Pauk, K.; Řezníčková, E.; Dušek, J.; Hanusek, J.; Kryštof, V. Substituted 2-hydroxy-N-(arylalkyl)benzamides induce apoptosis in cancer cell lines. European Journal of Medicinal Chemistry 2013, 68, 253-259. [ISSN: 0223-5234, IF2012 = 3.499].
  2. Sedlák, M.; Pejchal, V.; Imramovský, A.; Hanusek, J. A Safe and Efficient Route For The Preparation of Nitro-, Dinitro-, and Trinitrofenyl Chloroformates. Synthetic Communications 2013, 43, 2365-2369. [ISSN: 0039-7911 print=1532-2432 online, IF2011 = 1.062].
  3. Pejchal, V.; Imramovský, A. Development of optimised synthesis of 4-amino-N-(4-carbamoylphenyl)benzamide for industrial application. Research on Chemical Intermediates 2013, 39, 2237-2244. [ISSN: 1568-5675 (electronic version), ISSN: 0922-6168 (print version), IF2011 = 0.697].
  4. Imramovský, A.; Pejchal, V.; Štěpánková, Š.; Vorčáková, K.; Jampílek, J.; Vančo, J.; Šimůnek, P.; Královec, K.; Brůčková, L.; Mandíková, J.; Trejtnar, F. Synthesis and in vitro evaluation of new derivatives of 2-substituted-6-fluorobenzo[d]thiazoles as cholinesterase inhibitors. Bioorganic & Medicinal Chemistry 2013, 21(7), 1735-1748. [ISSN 0968-0896, IF2011 = 2.921].
  5. Imramovský, A.; Grusová, L.; Beneš, L.; Pejchal, V.; Sedlák, M. Synthesis and characterization of pH-sensitive conjugate of isoniazid – methoxypoly(ethylene glycol)-b-poly(L-lysine). Bioorganic & Medicinal Chemistry Letters 2012, 22(18), 5952-5955. [ISSN 0960-894X, IF2011 = 2.554].
  6. Bílková, E.; Imramovský, A.; Sedlák, M. Recent Advances in the Design and Synthesis of Prednisolone and Methylprednisolone Conjugates. Current Pharmaceutical Design 2011, 17, 3577-3595. [ISSN: 1381-6128, IF2010 = 4.774].
  7. Imramovský, A.; Monreal, J. F.; Pauk, K.; Krátký, M.; Vinšová, J. Synthetic Route for the Preparation of 2-Hydroxy-N-[1-(2-hydroxyphenylamino)- 1-oxoalkan-2-yl]benzamides. J. Comb. Chem. 2010, 12(4), 414-416. [ISSN 1520-4766, IF2009 = 3.450].